Natural compounds like berberine are becoming increasingly touted as a way to support healthy aging as we continue to seek longevity in health and wellness. Berberine is known for its metabolic, anti inflammatory and antioxidant properties and has been gaining a lot of attention for its potential to target the root causes of aging at the cellular level. In this article, we look at how berberine can help you stay healthy and young, and why it might be just the natural ally you need to combat time.
How Does Aging Occur?
Aging is a multiple factor process characterized by oxidative stress, chronic inflammation, and mitochondrial dysfunction. Together they lead to cellular damage and aging related diseases like cardiovascular disease, cognitive decline and metabolic disorders.
The decline of AMPK (adenosine monophosphate-activated protein kinase) activity, one of several cellular enzymes that help regulate energy balance and metabolism, is believed to be one of the key processes of aging. When AMPK activity goes down, the body is no longer able to regulate its energy use efficiently and fat accumulates and cellular function declines.
How Berberine Helps Slow Aging
AMPK, which activates power metabolism and helps keep cells healthy, can also be activated by berberine. Research in Cell Metabolism finds that activating AMPK mimics caloric restriction, a well studied method for increasing lifespan . Berberine works by activating the AMPK, which helps the cells create energy, burns fat, and increases autophagy, the process by which the body disposes of damaged cells.
Dr. Yibin Feng, a professor at the School of Chinese Medicine at the University of Hong Kong, emphasizes that "AMPK promotes autophagy directly by phosphorylating autophagy-related proteins in the mTORC1, ULK1, and PIK3C3/VPS34 complexes or indirectly by regulating the expression of autophagy-related genes downstream of transcription factors such as FOXO3, TFEB, and BRD4”. As such, berberine is a valuable tool for anyone wanting to age on a cellular level.
Anti-Inflammatory and Antioxidant Properties
Aging is driven largely by chronic inflammation, of which arthritis, diabetes, and cognitive decline are examples. Various studies have well documented Berberine’s potent anti inflammatory effects. For instance, a recent study published found that berberine significantly reduces inflammatory markers such as TNF-alpha and IL-6, both being linked directly to aging.
Another study published in the National Center for Biotechnology Information (NCBI) also highlighted berberine’s ability to reduce oxidative stress, which is a big contributor to cellular aging and DNA damage. By reducing inflammation and oxidative stress, berberine not only supports overall health but also combats some of the key drivers of aging.
Berberine’s Impact on Cognitive Health
Cognitive function becomes a concern for many of us as we age. The neuroprotective effects of berberine have shown promise in protecting from cognitive decline and disease such as Alzheimer’s. A Journal of Neuroinflammation study found that berberine reduced brain inflammation and damage from oxidative stress in animal models, and could help preserve cognitive function in aging populations.
Dr. Rhonda Patrick, a leading voice in aging and neurobiology research, explains on the Huberman Lab podcast, “The anti-inflammatory and antioxidant properties of compounds like berberine are particularly important for brain health, as they help protect neurons and improve cognitive resilience as we age.”
Cellular Longevity and Telomere Protection
Telomeres, the protective caps at the ends of chromosomes that shorten with each cell division, are one of the most intriguing areas of research on aging. The shortening of telomeres is associated with cellular aging and many age related diseases. Recent research even shows that berberine may prevent slow down telomere shortening, thereby prolonging cellular lifespan and prolonging life.
Why Choose Maya’s Metabolism+ for Healthy Aging?
At Maya, we understand that aging gracefully requires a holistic approach. Our Maya Metabolism+ formulation is designed to support healthy aging* by targeting the underlying causes of cellular degeneration*. By promoting AMPK activation*, reducing inflammation*, and supporting cognitive function, Maya’s Metabolism+ helps you maintain vitality at any age.
How to Use Maya’s Berberine Complex
For optimal results, take Maya’s Metabolism+ twice daily with meals. This will help activate AMPK through berberine*, reduce oxidative stress*, and support cellular health* throughout the day. Always consult with your healthcare provider before starting any new supplement regimen, especially if you are managing existing health conditions.
METABOLISM+
The Sidekick You’ve Been Waiting For
Our breakthrough formula helps boost your metabolism, curb cravings, and keep you feeling full.*
